Antigen structure affects cellular routing through DC-SIGN
نویسندگان
چکیده
منابع مشابه
DCIR triggering affects DC-SIGN mediated routing
5 135 DCIR follows a different intracellular route Besides a possible effect on the internalization capacity, simultaneous triggering of CLRs could also affect intracellular routing of antigen. The endo-lysosomal targeting, described for all four CLRs 15,20,27,31 , could be one indication of the existence of a common intracellular routing pathway. In that case, CLR ligands would co-localize aft...
متن کاملThe simultaneous triggering of DCIR and DC-SIGN hampers DC-SIGN-mediated endo-lysosomal routing
Several C-type lectins (CLRs) are expressed on dendritic cells (DCs). CLRs are carbohydrate-specific receptors involved in the recognition of glycosylated antigens. The interaction of CLRs with their ligands facilitates antigen internalization and can induce signaling or modulate TLR-induced signaling responses. Here, we investigated the internalization characteristics of four different CLRs: M...
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The C-type lectins DC-SIGN and DC-SIGNR bind mannose-rich glycans with high affinity. In vitro, cells expressing these attachment factors efficiently capture, and are infected by, a diverse array of appropriately glycosylated pathogens, including dengue virus. In this study, we investigated whether these lectins could enhance cellular infection by West Nile virus (WNV), a mosquito-borne flavivi...
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Dendritic cells (DCs) are known to be the most powerful professional antigen-presenting cells so far. It could activate primary immune response, and also downregulate immune response. DCs have a unique character of immunoregulation. DC-SIGN, a molecule designated as CD209, is one member of the C-type lectin superfamily. It is not only a pattern recognition receptor but implicated in immunoregul...
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The role of dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) in DC-T cell communication was assessed by analyzing the effect of DC-SIGN-blocking mAb in MLR. The results show that the degree of inhibition by DC-SIGN and LFA-1 mAb depends on the magnitude of the MLR and the maturation status of the DC. Addition of DC-SIGN mAb at several time-points during MLR showed that DC-SIGN is i...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2019
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1820165116